Chimeric antigen receptor–engineered T cells therapy has become the hottest topic of immunotherapy, as its great successes achieved in treating refractory hematological malignancies. These successes also paved the road to novel strategies of treating various solid tumors including liver cancer. Many specific proteins can be expressed aberrantly in liver cancers; therefore, a series of experimental and clinical researches exploring chimeric antigen receptor–engineered T cells and liver cancer are in progress, acquiring obvious antitumor effect and revealing its feasibility in treating liver cancer. However, lots of challenges and obstacles are emerging simultaneously, such as low infiltration, side effects, safety of chimeric antigen receptor–engineered T cells, and limited data of studies or clinical trials. Researchers have been working out many innovative ways to directly stroke these obstacles, theoretically or practically. This review focuses more on the progress and obstacles from chimeric antigen receptor–engineered T cells therapy to treat liver cancer, summarizing new breakthroughs in shooting those obstacles, meanwhile, hoping to provide enlightenment to this promising immunotherapeutic method.
as far as banks go i have been thouroughly screwed by every bank i have ever been involved in whether they would hold payments until they knew i would overdraft or they simply took out money for no reason they wont reimburse you there is no such thing as a bank error in your favor they only want to hold you to the rat race it sux but no banks are not the way for me. and im sure most on this site will agree
I have been sleeping in my car since 2010 and always have cats with me. In addition I rescue cats and dogs and foster cats, and also spay/neuter feral cats. It certainly can be done if you are able bodied. If you can barely care for yourself I would not add pets to that. But that is not the issue, first of all, get your cat used to being an indoor/outdoor cat. that is go in and out of the house (if you do NOT live on a busy street.) Then have the cat go into the vehicle instead of the house – when it wants an indoor setting of peace, quiet, safety, food. Make sure you put a litter box on the floor. Then travel a bit in the vehicle with your cat there. Don’t let him or her out. Just drive around and then sit at a park for several hours studying or something. Do that several times.
I have read most of these post and there is a lot of good advice in them. To the people trying to keep cool; I lived in my old Ford Aerostar last year for about two months. It was pretty warm — but I always tried to keep it in the shade during the day because if it is in the sun..it retained the heat at night. I went to Home Depot and got one of those vent covers for a couple bucks and cut a hole in the side of my van – low to the bottom and installed the vent. Then I purchased a $10 inverter and a 12 volt Ryobi batt operated fan to place in front of the vent to draw outside air. It seemed to work pretty good. On a full charge it ran most of the night. Fast forward to now….. I am now living out of my new van and realize how much more I spend on gas since I have to drive around a lot. At first I kind of liked it. I got a mini laptop which holds a charge for over three hours and I downloaded a lot of documentary’s to watch, but lately I am getting a feeling of hopelessness. I know/hope it will pass as I have a job out of state coming up in April 2013 that I can make some pretty good money on. I am a contractor and sometimes make pretty good money, but from the times I didn’t make good money — I went well in debt. I don’t want to give up my Credit score, so I’ve opted to live this way. I sometimes think I should just let my credit go and not worry about it but that thought scares me as I am 53 years old and want to buy a house when I can save up enough money. I have found that if you can park your car beside a library at night you can get free wi fi. I also have a gym membership. I have been doing this for 24 days. I broke up with my partner of 10 years. He was fine with us until he got his masters and a good job and then he didn’t need me anymore, which is the best thing for me anyway. Just have to get over the feelings since I am sensitive and it still hurts. I haven’t told any of my friends or family I am doing this. I would be so embarrassed — I just couldn’t–hubris I guess. My friends and family ask me all the time where I am staying now and I tell them “with a friend”. I am happy that some people find this enjoyable…I’m sure that helps–but for me it is not fun at all. But I will do what I have to do but I hope this will be the last time I have to do it.
Hi inspiring people. I’m from San Diego and houseless too. I’m a short & asian who lives in my honda civic coupe. I was forced to move out of my gf’s apt due to a bad break-up, but anyways, it’s been a month that I’ve been sleeping in my car. Our building at work is open 24 hours so I stay most of the time at our parking garage. Hope everyone is doing well and don’t hesitate to e-mail me if you feel like chatting or whatever. Take care.
Thanks so much for this! I’m a broke college student in LA. 100% of my loans and work income goes to rent and food, which costs more than my tuition. I’m basically going years into debt just to have a roof over my head. So I’ve been looking quiet seriously into living out of my car at least until I’m out of school and can get a stable income. Your tips are very practical, starting with working with the car you have. Thanks for this!
I have been sleeping in my car since 2010 and always have cats with me. In addition I rescue cats and dogs and foster cats, and also spay/neuter feral cats. It certainly can be done if you are able bodied. If you can barely care for yourself I would not add pets to that. But that is not the issue, first of all, get your cat used to being an indoor/outdoor cat. that is go in and out of the house (if you do NOT live on a busy street.) Then have the cat go into the vehicle instead of the house – when it wants an indoor setting of peace, quiet, safety, food. Make sure you put a litter box on the floor. Then travel a bit in the vehicle with your cat there. Don’t let him or her out. Just drive around and then sit at a park for several hours studying or something. Do that several times.
COOL! I am in a camry too. Camrys are actually kind of big inside so its.. slightly, more comfortable than an average car. I also made a bed! But took out the whole passenger seat to do it.. and boy do the cops notice that seat missing. Are you able to stretch your legs out in yours?… what sounds like is that you are laying across passenger and back with legs going into the trunk? ITs so hot in summer I can’t even use the bed since its in the floor.. end up just using the driver’s seat. The seats can recline a little bit further if the back seat cushion is gone.
Researchers studied over 50,000 people who had suffered liver injuries as a result of a car accident. People whose liver injuries were severe were twice as likely to lose their lives as those whose injuries were considered mild or moderate. Drivers and passengers who wore seat belts during the crash were less likely overall to suffer a severe injury to the liver and thus more likely to survive. Airbags could further reduce the risk of a severe injury; however, when used without a seat belt, they had no impact on the likelihood of severe damage.
I understand what you are saying. I have thought about this and have decided to try the hotel parking lots. Not many police go through those (at least, not the nicer ones) and I would park in back. As far as dealing with police, I would just tell them, I am temporarily sleeping in my car for a set amount of time. I have to be honest. I don’t know how anyone could sleep in a Wamart parking lot, too much noise and activity. Hotel parking seems the most logical, safe, quiet place to be.
I do have a judgmental comment but it is not at all directed at LIMH personally. Am I the only GRS reader who finds it totally pathetic that affordable housing in the U.S. is so difficult to come by? This is reminding me of a story in “Nickel and Dimed” by Barbara Ehrenreich. I don’t have the book in front of me, but I recall in one chapter how she’s working as a Merry Maid and finding out one co-worker is living out of his car and others are in weekly motels because there’s no affordable housing. One of the main points of the book is that it is nearly impossible to find adequate housing on a low salary. So much for the supposed greatest country in the world…
This is an extreme (for most of us) commitment to becoming debt-free. While not feasible for me and my family, I commend you for being willing to do whatever you felt necessary to dig yourself out of debt. This journey will certainly teach you new skills! And you will be able to look back at this time, knowing you never want to get back to this place again. What motivation for responsible money management!
I, however, live on the East Coast. Some circumstances are quite different. For instance, it sounds like in the West gym memberships are expensive. Mine is $16/month. Out West there are legal disputes over whether a person can live in her car or where she can park. I can’t find anything pertaining to the East Coast except that in New York City it’s legal.
I’ll tear through the “hows” and “whats” really fast to get the interesting stuff. Car: 2002 Honda Civic EX Coupe. Shower: YMCA (I got a discounted rate for having low income; I think it was $16/month). The YMCA is great because it has soap/shampoo/conditioner/towel there. I would usually go for a run before I showered, too. Work: Hacker Dojo. Eat: nonperishable stuff. Sleep: “slim twin” air mattress meant for sleeping on cots, blown up halfway, feet in the trunk, head by passenger seat. Find an empty church parking lot for privacy. I didn’t tint my windows, which probably would have made sense, but I just didn’t care.
ALS Society Alzheimer's Alzheimer Society autism Autism Ontario back to school Bullying Canada Calgary canadian cancer society Canadian Red Cross cancer car charities charity charity of choice children Children's Wish Foundation Christmas donate donate a car Donate a Car Canada Donate a Vehicle Donate My Car Donate your car generosity Giving Health homeless inn from the cold junk car kidney car kidney foundation kids help phone Pick and Pull Pick n Pull recycle Red Cross Rescue scrap car Support tax receipt vehicle Vehicle donation Vehicle Donation in Canada Youth
I usually use these during the day, when resting, reading, or napping. because I have ones with the hour-limit. Use them on my lap or for a cold stomach. when you are cold in one place, like your lap, your whole body will feel cold and it really is not. Good warmth from one area, like your lap, which is a large area, also spreads quickly to other parts of you.
Another core idea is to live “out of” the car rather than “in” the car. Spending all of your time in a small space can be claustrophobic. Sleeping (and possibly working) in a car while you spend the remainder of your time outdoors is much easier to manage. In my case, I slept and worked in the car (I am a digital nomad), but otherwise spent as much time outdoors as possible.
After infusing abundant highly reactive CAR-T cells, especially the second and third generations, a bunch of inflammatory cytokines can be released to the blood circulation that may be related to the leakage of costimulatory signals or the lower threshold of T cells activation. This phenomenon can result in fever, hypotension, hypoxia, neurologic changes, and even acute respiratory distress syndrome or multiple organ dysfunction syndrome; this range of clinical and laboratory findings has been termed a cytokine release syndrome (CRS).51 Predicting CRS is difficult due to the limited utilization of CAR-T cells to treat solid cancers in clinical practice, which may also be different from those observed in leukemia and lymphoma, but we can also take it as a reference.

Pet warmers DO NOT use 6 watts of power. I know I made this comment elsewhere, but just incase some one reads this other posting above, I am just posting my response here also. I have pets, electrical pet warming pads (medium size), marine deep cycle batteries and heating pads made for people. PET WARMERS USE AT LEAST 50 watts, sometimes more, like 70 watts. The 6 watts has to do with the switch that is continaully on. When a cat walks on the pet warmer, when it detects a pet, then the heating wires turn on. It takes 6 watts to keep on that electrical device that detects the weight on the pad. that is why it says the continual wattage use is 6 watts.
I have been living in my car for going on two years. For me it is a choice. People make it out to be harder than it really is. The worst thing that I have found is that people assume that you don’t work or pay taxes. I do both. If you are in some lots a little too long, then I have had people tell me then are going to “call the police to check me out.” They assume I must have some kind of criminal record or something. The police don’t bother me as I have never been arrested and I don’t cause any trouble. The only advice an officer gave me was not be at the same place in any kind of pattern so criminals wouldn’t decide to steal from me. I have paid everything off but my student loans. I probably will do this for at least a couple more years until the student loans are paid off as well.
Cut cardboard exactly the size off your windows and spray paint em black on the side that faces out the windows. This works great if you have partially tinted windows. You want to face your car so the front is on the least likely side to be viewed. For the windshield I recommend reflectix because many people have windshield covers so this is inconspicuous. (can be bought at most hardware stores)
Consumer Reports is an independent, non-profit organization dedicated to helping consumers. We make it easy to buy the right product from a variety of retailers. Clicking a retailer link will take you to that retailer’s website to shop. When you shop through retailer links on our site, we may earn an affiliate commission – 100% of the fees we collect are used to support our mission. Learn more. Our service is unbiased: retailers can’t influence placement. All prices are subject to change.
In the 1880s a severe liver injury would in most cases prove fatal in the first 24 hours after sustaining the injury.[15] Before the 1980s nonoperative management was seldom used in favor of the methods of management suggested by James Hogarth Pringle.[16][17] During World War II the use of early laparotomy was popularized and in conjunction with the use of transfusions, advanced anesthetics, and other new surgical techniques led to decreased mortality.[18]
×