We used ob/ob and ob/ob CAR−/− double mutant mice to investigate the role of CAR in T2D. Our results show that the antidiabetic effects of the more specific CAR agonist TCPOBOP (TC) are lost in the double mutant mice, and that activation of CAR significantly affects both glucose and lipid homeostasis. In particular, CAR activation represses gluconeogenesis, while increasing hepatic glucose uptake and utilization. It also represses lipogenic gene expression via a mechanism dependent at least in part on inactivation of oxysterol ligands for the liver X receptors LXRα and β, and increases β-oxidation via an unexpected pathway associated with decreased expression of acetyl-CoA carboxylase 2 (ACC2).
Nicole Cutler, L.Ac., MTCM is a long time advocate of integrating perspectives on health. With a Bachelor's degree in Neuroscience from the University of Rochester and a Master's degree in Traditional Chinese Medicine from Five Branches Institute, Nicole has been a licensed acupuncturist since 2000. She has gathered acupuncture licenses in the states of California and New York, is a certified specialist with the National Acupuncture Detoxification Association, has earned diplomat status with the National Commission of Chinese and Oriental Medicine in Acupuncture and Chinese Herbology and is a member of the Society for Integrative Oncology. In addition to her acupuncture practice that focuses on stress and pain relief, digestion, immunity and oncology, Nicole contributes to the integration of healthcare by writing articles for professional massage therapists and people living with liver disease.
Step 1- Get a set up that you like. One of the main purposes of living in your car is to save money, so don’t go buy a new Sprinter van. Find a way to make it work with what you’ve got. So you have a small car? Can you take out the back seats or open the trunk up to the front? Problem solved. If you have a truck, then get a camper cover so you can live out of the back. If you have a SUV (like me) just fold the backseats forward.
Lots of people say they are CHRIST ian and are not. lots and lots and lots. good and evil people. It is not a fact that she is a CHRISTian. you certainly don’t know either. Do not be hateful of people living in that situation or on less because CHRIST and the APOSTLES lived on less and were hated. I don’t know what she is or what you are. you sure assume that you know me and her also.
I have read most of these post and there is a lot of good advice in them. To the people trying to keep cool; I lived in my old Ford Aerostar last year for about two months. It was pretty warm — but I always tried to keep it in the shade during the day because if it is in the sun..it retained the heat at night. I went to Home Depot and got one of those vent covers for a couple bucks and cut a hole in the side of my van – low to the bottom and installed the vent. Then I purchased a $10 inverter and a 12 volt Ryobi batt operated fan to place in front of the vent to draw outside air. It seemed to work pretty good. On a full charge it ran most of the night. Fast forward to now….. I am now living out of my new van and realize how much more I spend on gas since I have to drive around a lot. At first I kind of liked it. I got a mini laptop which holds a charge for over three hours and I downloaded a lot of documentary’s to watch, but lately I am getting a feeling of hopelessness. I know/hope it will pass as I have a job out of state coming up in April 2013 that I can make some pretty good money on. I am a contractor and sometimes make pretty good money, but from the times I didn’t make good money — I went well in debt. I don’t want to give up my Credit score, so I’ve opted to live this way. I sometimes think I should just let my credit go and not worry about it but that thought scares me as I am 53 years old and want to buy a house when I can save up enough money. I have found that if you can park your car beside a library at night you can get free wi fi. I also have a gym membership. I have been doing this for 24 days. I broke up with my partner of 10 years. He was fine with us until he got his masters and a good job and then he didn’t need me anymore, which is the best thing for me anyway. Just have to get over the feelings since I am sensitive and it still hurts. I haven’t told any of my friends or family I am doing this. I would be so embarrassed — I just couldn’t–hubris I guess. My friends and family ask me all the time where I am staying now and I tell them “with a friend”. I am happy that some people find this enjoyable…I’m sure that helps–but for me it is not fun at all. But I will do what I have to do but I hope this will be the last time I have to do it.
I’m so glad I came across this website. I have a new 2 door Ford Focus hatchback I’m still paying for. My life has turned around completely in the last year and I am in so much credit card debt and I don’t have a job. My unemployment benefits is not enough to rent a room, eat and pay my car. I need my car, I don’t want to lose it so I want to make sure I can afford the payments. I plan to lower my expenses to a minimum. I’m planning to shower and get ready for work at the gym and I’m going to rent out a storage unit for my clothes and other important things for $50.00. a month and I plan to get a P.O. Box for the “bills” to come in. I have a cell phone and I could always use a computer for free at the library. Thank goodness I live in Southern California so the weather will never get below freezing. I’m petite so sleeping in the back seat of my car is comfortable enough. The only thing I was a bit worried about is where to park with out being noticed. I read Walmart mentioned a couple of times in this website. The Walmart in my area is in a big shopping center with other stores surrounding it. I’m not sure if I could do that.