It is a shame to read how average people have to pay hgh rents for a small apartment. There is not any bailout for renters, and with people losing homes, the rental market is gourging people!!! They make you pay for water besides the rent. I am ready to write McCann and ask may I housekeep one of his homes.He has 7 or more, I am willing to housesit, since my rent takes most of my SS check!! I worked very hard all my life and I am not poor or rich, but with the rising prices, I may have to put everything in storage and volunteer to live at a homeless shelter. I have some savings, but I am using it to supplement my SS and a part-time job. The people shipping jobs overseas and bringing in foreign workes should lose all their money to Bernie Madeoff. He made off with the crooks money…lol One rich woman said she was down to living in one home…She had to sell three. Poor baby!!!!!

Previous studies have shown beneficial effects of PB on insulin sensitivity in both mouse models (8) and human T2D patients (8, 9), but the basis for these antidiabetic effects has been unclear. We used two complementary approaches to critically test the hypothesis that CAR mediates these effects. The first is the pharmacologic substitution of TC, a much more specific mouse CAR agonist that does not activate AMP kinase, for PB. The second is the genetic introduction of the CAR−/− allele into the ob/ob mouse model of obesity and T2D. TC induces antidiabetic effects very similar to those described for PB in the ob/ob model, and those effects are lost in the ob/ob, CAR−/− double mutants, definitively establishing CAR as the mediator of such antidiabetic effects. While this manuscript was in review, similar antidiabetic effects of TC were reported (24). TC treatment decreased body weight in those studies, possibly due to toxic effects that do not occur in our mice. This decreased body weight could amplify the antidiabetic effect, but is clearly not essential for the TC activity that we observed or the previous results with PB, which also did not decrease body weight (8).
Whenever my ship pulled into home port I would live out of my car. It was quieter that being around a bunch of loud rude drunken sailors. As an example I was awakened one night by the fellows playing darts and one came in my rack and hit my pillow 3/8ths of an inch in front of my eyes as I lay there sleeping. On another night I was awakened by a drunk vomiting on the deck by mt rack and the stench. I had to get up and clean the mess while he slept it off. Then I had… Read more »

The first step we need to face is defining the specific TAAs. As we all know, CD19 which expressed throughout B cell development and presented on almost all B cell malignancies has been detected as an excellent TAA for generating specific CAR-T cells. In this case, we wonder what the standard for defining an ideal TAA is. Marcela et al. summarized the requirements for discriminating a suitable TAA for engineering CAR-T: (1) definite targets must be expressed on the cellular surface of definite tumors; (2) ectopic expression of the target must not be present in the essential organs or cell type, even at a low level; and (3) the target must be expressed on all the tumor cells, or alternatively, the target must be requisite for the maintenances of tumorigenic phenotype.21
The smallest Goal Zero solar-powered generator, the Yeti 400, is capable of storing enough juice to recharge your laptop five times. The largest, the Yeti 1250, will recharge it 20 or more times. Pair those with a couple solar panels—the Boulder series pairs great with Yeti generators—to fully sustain your AC-power needs without ever taxing your vehicle’s battery or alternator.
You’ll quickly be able to tell where people can park overnight, since a bunch of other cars will also be there. Neighborhoods filled with apartments are a good option because most residence have to park on the street anyway. But make sure you don’t need a permit to park overnight there, or else you could end up being towed while you’re still in the van…not fun.
I’ve lived out of my car on and off in the past year, as a voluntary experiment with the vagabonding lifestyle. Large and mid-large SUV’s, when their seats are folded down, create a flat platform which functions as a good sleeping base. A mattress pad makes good cushion, and best of all, absolutely no one suspects an SUV parked overnight at Walmart to harbor a sleeping person, especially with the tinted rear windows. Space is rather limited though, and acrobatics are necessary to enter the sleeping section. If you are on an extreme budget, a rag and some soap in… Read more »

This is the same advice I would give to any child or teenager who is going through liver disease. Sometimes, a disease can make you feel different and alone. But, this experience will only make you stronger. I choose to see my illness in a positive light. Without it, I wouldn’t have experienced the countless opportunities to educate and inspire anyone inside or outside of my community, and of course, I wouldn’t have been able to raise the awareness of liver disease.

One last thing is if anybody has the option of a shelter or living there car, always choose a car. Even if you cant afford fuel, you can always park it a couple days and move it and so on. All a shelter gives you is shelter (what your car provides you and so much more). What they take from you is your pride and most importantly your freedom. They say you have to be in at a certain time, you have to leave at a certain time and a gazillion other rules nessary to efficiently manage such a place. Maby you can only have so much stuff ets… Lots of rules that take away your freedom and pride a tiny bit at a time till its all gone. I have never been in a shelter so could be wrong. The free meals and showers offered by shelters I think you can get without sleeping there probably depends on which shelter. A lot of drug users people with mental disorders ets use the shelters. Which means risk of theft, loss of safety, lots of potential diseases ets is always a present risk. Probably quite a few disruptive people ets. Once you figure it out temparily living in a car is something you can do, and you still you have all your freedoms, your life revolves around you not some institution used mainly by less-desirables. Live in your car, look for work, keep yourself clean and in shape, spend time in the parks, libraries ets.. Life could be worse, how I choose to cope with the hard time I am facing hope something I said helps somebody else cope a bit easier.
I’m sorry, but what you are promoting is illegal in many cities. Not only is it illegal, but it places a burden upon the business owner when you sleep on their property. While many businesses have umbrella insurance to cover a case where someone might be hurt or harmed on their property (say you are robbed or assaulted because you failed to lock the doors), then technically they could be sued and hence the business owner becomes very irate at what you’ve done. Not a good idea. There are lots of places where these city wide bans are enforced because… Read more »

Let’s face it, we’ve all romanticized about life on the open road. Whether you’re an avid Kerouac reader, traveling surfer searching for the perfect wave, or simply looking for a life with a little less contemporary responsibility and a little more contemplation, living out of our cars is something we as a culture associate with adventure – provided of course that this is a lifestyle of choice, not forced into out of necessity.
To test whether diabetes and obesity affect CAR activity, 10-week-old ob/ob and ob/ob CAR−/− mice were treated with the CAR specific agonist TCPOBOP (TC) for a week. As expected, expression of CAR targets Cyp2B10 and Cyp3A11 were robustly elevated in the TC-treated ob/ob mice, but not in the ob/ob, CAR−/− mice or vehicle treated ob/ob mice. Thus, the ob/ob background has no apparent effect on either the basal activity or the agonist response of CAR (Fig. S2).
I live in Florida. I’m 49, married and have two kids who are about to start college. My wife and I met in college and have been working in corporate America since we were teenagers. We are doing very well and life has been simple but good to us. However, I’m terribly overweight and suffering from anxiety and general lack of interest. Physiologically, I’m getting near my breaking point. Lately, all I do is dream about running away from everyone and everything. Even though our net worth is very high, I dream of buying a VW Budd-e EV Van and living out of it with just a cell phone, laptop and 3 pairs of jeans. I imagine I could shower in 24 hour fitness and eat out every day. I could just drive up and down the east coast, parking at the beach or charging stations near points of interest. Just to test the theory, I’ve take short hall-pass trips for 2 – 3 day and done it. It felt amazing and liberating to not to have a schedule to be that free. I never felt unsafe or uncertain like I do in my regular life.
A lot of Walmarts allow you to park in their lots to sleep. Try fire department parking lots too. Firefighters are laid back and if you tell them about your situation they will allow you to park there. They’ll become very used to your presence too. Working nights is the best because you can park almost anywhere during store hours, but the choice is yours.
Public barbecues can be handy, but it’s quicker and more reliable to have your own camp stove, such as the easy-to-pack “Firebox”. Never attempt to operate any camp stove inside your vehicle for safety reasons. For cleanliness, try to do all food preparation and cleanup outside of the car as well, such as at a public park, where picnicking is encouraged.

I usually use these during the day, when resting, reading, or napping. because I have ones with the hour-limit. Use them on my lap or for a cold stomach. when you are cold in one place, like your lap, your whole body will feel cold and it really is not. Good warmth from one area, like your lap, which is a large area, also spreads quickly to other parts of you.
I have a solar panel set up myself and I looked at the Yeti 400 at Goal Zero Solar website. You could really save a lot of money getting some solar panels and charge controller from Renogy. They are also online. You have to purchase your own battery and also an inverter, but you can get a lot more power for a lot less money. I can give you the details of my set up if you like. Camping in this country is designed and almost designated for professional people who have money. all the gear is ridiculously expensive and even kind of vain. It is not real camping. If you study the laws and rules or talk to rangers about the “right” way to camp, it would cost you thousands of dollars. That is not camping at all. Just like turning everything else into extreme money for the wealthy. The gadgets are not that complicated. Please do not purchase a 20 watt foldable solar panel for $199 that goes with the Goal Zero Yeti 400. I know you do not have that kind of money!
Food for thought. One thing I don’t understand though. Rent is expensive but some people here are talking about how they couldn’t pay their rent, and cell phone, etc. Doesn’t it make more sense to get rid of every unnecessary bill (cell phone, internet, etc) before giving up a home? When I was on a very low income I found a very small studio flat and simplified everything else in my life – didn’t have a TV (no TV bills), didn’t have the internet (you can use library computers for free), didn’t have a cell phone, but walked to my friend’s flats for entertainment. The one thing (I personally) think you need is running water, I can cope with no electricity but not no water!!!! You can eat very cheaply if you stick to very simple foods, have a fridge (if you keep the electricity) and make everything in bulk and store it. For some bills the expenses will be more in a car (such as food, and also needing a gym membership). I can understand avoiding houseshares. I was a lodger for 5 months and I would rather have stayed in my car, it was HORRIBLE. Having said that some houseshares do work. Either you have to find genuinely OK people or people who keep themselves to themselves. I just don’t like the thought of people having to live in their cars, having said that it’s better than a hostel and the problems that come with that. As for me, well, my life turned around when I managed to land a better paid job and then had some pay rises, it’s double what I used to be on. But funnily enough I don’t think I’m any happier. Different problems replaced the money problems I had before. Good luck to everyone.
Tires are the only part of your car that touches the road. And they’re especially important when logging tons of miles, particularly when those miles are on dirt or gravel roads or in extreme weather. Tires that come stock on most vehicles are usually garbage and underperform in virtually all road conditions. Instead of refitting the stock rubber when it wears out, upgrade to something more suited for the road less traveled. Upgrades are often cheaper than the tires your van came with.
Those survival blankets? the ones that look like aluminium foil? they are good. It takes a lot to rip them, they are cheap and take up hardly any room in a pack. If you are in a tent or a hammock wrap yourself in one of those emergency blankets and then get into your sleeping bag. Socks, hat, gloves. If you choose a hammock, get one without a space bar and made of parachute nylon which folds up small, Ticket to the Moon makes a good one, buy a double size and sleep in it diagonally, that way your body will be flat and not like a banana. Hennessey is good too. Maybe tape another foil blanket to the surface of your hammock underneath. If you put the foil between hammock and sleeping bag it gets all scrunched up. good luck. If your pool showers have cubicles you can shave and clean teeth in the shower where no one will see.
I live in Florida. I’m 49, married and have two kids who are about to start college. My wife and I met in college and have been working in corporate America since we were teenagers. We are doing very well and life has been simple but good to us. However, I’m terribly overweight and suffering from anxiety and general lack of interest. Physiologically, I’m getting near my breaking point. Lately, all I do is dream about running away from everyone and everything. Even though our net worth is very high, I dream of buying a VW Budd-e EV Van and living out of it with just a cell phone, laptop and 3 pairs of jeans. I imagine I could shower in 24 hour fitness and eat out every day. I could just drive up and down the east coast, parking at the beach or charging stations near points of interest. Just to test the theory, I’ve take short hall-pass trips for 2 – 3 day and done it. It felt amazing and liberating to not to have a schedule to be that free. I never felt unsafe or uncertain like I do in my regular life.
I still have to pay for gas and so forth, but I am “out there” all day. I don’t feel lonely as I would in my house and I love not having to pay heating for the whole condo. I had a problem with knots in my shoulder from working on the internet bent over in my car but I found if go to the gym and use the exercise equipment for my shoulders and pull on weights and life stuff then knots are not a problem anymore.

What am I missing as a regular expense? Obviously, It’d be nice to afford a gym membership but saving is more important to me and, I’ve been homeless before and it’s not that tough to find a place to shower plus, I have a pocket puppy who needs exercise, too. We can hike in the winter and swim in the summer. Velcro attachable weights don’t take up much room.

Get a car alarm, keep your car clean by visiting the “do it yourself car wash” with the spray hose that takes quarters. Possibly keep a stun gun or pepper spray (or bear spray) in your car with you. Add one way mirror, mesh, or dark tint to the inside of your camper topper and park at Wal-Marts or campgrounds. Maybe offer to rent the driveway space at a friends house – don’t abuse the system! For those of you with truck toppers, try to enter into the bed area using the pass through window of the cab, that way you don’t draw unnecessary attention to what you’re doing. Park in well lit areas where other people may be present, if you can’t afford a real car alarm get the fake red LED flashing kit (this one is solar powered and shock sensitive) this one is a bit cheaper.

The first step to ensuring that you’re safe is to be sure people aren’t immediately aware that you are living inside the car. You will have to make your own custom stealth solution depending on what type of vehicle you have, whether your windows are tinted or not, where you park, and whether or not you emit lights from your vehicle. If you drive around in a van with no windows, or a very obvious campervan, you are already at a disadvantage because these vehicles arouse suspicion and people may be more apt to call the cops or disturb you. Keep these considerations in mind if you haven’t chosen a vehicle yet. Some general tips here are helpful:
I am in Michigan too. Please don’t use the candles as people have accidentally caught their cars on fire doing so. Think bumped candle. If you are going to get to sleep during the day then you are already ahead of the game because sunlight really does help to warm up your car during the day. Buy two sleeping bags and put one inside of the other. Use those “Grabbers or hot hands” (they heat up once opened from their package). They are made for your pockets. But a few in the bottom of the sleeping bag or your socks are heaven on a cold day. Be careful as they really warm up. Always crack a window or you will end up with a lot of condensation (water) in your car and it never dries during the winter. Always have a plan where you can go if it is just too cold. Remember the winter last year – there were days it never got above zero. I have a policy that I don’t sleep in my car if it is -15 or below. Good luck. You can do this even in Michigan.
YOU GO GIRL! I keep a paint scraper in my curtains pouch to push those things right up under the plastic rim around the top of the windows. Keeps everything tidy and hanging close to the windows. If it’s cold – you can use Reflectix from a store like Lowes for less than $20. A sun shield works well in the front window. I use see through bins under my Coleman cot when camping in our van for my dry goods, cooking supplies, clothes & bedding. I keep a nice folding camp chair alongside of the cot. I carry starter kindling for campfires. I can charge my phone while driving during the day, or use the charger on my little biolite stove while I cook. Have you ever tried cooking in double wrapped tin foil on your engine while traveling to the next town? I think I learned that from a Youtube video. I haven’t actually tried it yet – but it sounds like it would work. State Parks are awesome – they always have something special to be discovered in them, and not very expensive – plus the bathrooms are usually very clean and heated in cool weather. If you are traveling with a cooler – it works well to keep a smaller cooler inside the larger one. I’ve traveled for several days without having to re-freeze the coolies like that. If you use ice – you can let it melt into fresh drinking water. I use a re-chargeable plastic hanging lantern that recharges itself on very little sunlight during the day (d.light LED Solar Rechargeable). Just a few tips I learned from being on the road and wanting to stay organized. Have fun! You’re living my someday dream.
As far as times getting worse. A little worse yes, as far as crime goes that’s up. The ARM loans destroyed our economy. When the real estate bubble exploded, the mortgage rates broke record highs. A lot of folks were paying a high mortgage on a house of less value. But the ones with the ARMs really got f..ked. They should have stuck with a fixed mortgage rate. Their loans jumped from some families paying $200 per month up to $1,500 per month. The only way for the folks with the ARMs to save their homes was to completely eliminate all other expenses and just focus on their mortgages. No more movies, restaurants, bowling, vacations, new cars, etc. All these economic activities on the side were put on hold. NOT GOOD! So the car dealerships, etc. had to lay employees off because no money was coming in.
I, however, live on the East Coast. Some circumstances are quite different. For instance, it sounds like in the West gym memberships are expensive. Mine is $16/month. Out West there are legal disputes over whether a person can live in her car or where she can park. I can’t find anything pertaining to the East Coast except that in New York City it’s legal.
Yes cls, That is the date you first started to post. I have read all your posts and I know you’ve had a hard time. I;m moving for similar reasons. My neighborhood is crime ridden and my friend/landlord, ripped me off for 460.00. I am moving in a few days and I might park in a friends driveway or do the hotel parking thing. I do have a job, it’s just not enough. I don’t take drugs and I do not look like a “homeless person”. I wish we could rent/share an apartment..haha, since you and I are in so. cal. That was a joke, I’m not a stalker lol.
I heard in the news today that Mattel has come up with a new addition to the American Doll collection. Her name is Gwen Thompson and she and her mother are homeless and sleeping in a car. She has her story, dad ran off when he lost his job and her mom lost her job too so this poor little girl has no home just a car. She sellls for $95.00 Isn’t that something? It’s the “Sign of the times”

Hi,trucks tops are great places to stay. Most all have a tv room and there’s always Bored truckers that enjoy talking with a person. As for a shower. I keep DVDS on hand that I have watched and hang around around the machine where they get their shower ticket from and offermtomtrade amDVD forgone of their extra shower tickets, Works real well for me. I am not begging. I am battering, plus they have waste dumps. Nice people at the trucks tops.
I used to have an Astro Chevrolet van, I would only sleep in it after work. You see I would sleep 30 minutes or 45 minutes, before getting to the gym. I read somewhere in a magazine an article stating that, Americans are very sleep deprived. Due to long hours of work, poor eating habits, diseases and/or disorders the average American needs another half hour of sleep during the day. I tried to sleep at work during the lunchhour,but I couldn’t realy enjoy. You see I put a nice thick,padded sleeping bag in my truck, a pillow, and blanket. I felt so full of energy during that short nap. Mhhhjjjfff,, It felt so rewarding like when I was in kindergarden and I would sleep on the floor. Remember just clean up your body at work before getting to your van and get good quality earplugs. Take in mind that their are people with fancy bed matresses who have a hard time to sleep. In Mexico people sleep a siesta during their work hours, in some cities.
For heat when sleeping in car or truck the absolute best thing is electric blanket, in the northern areas and am sure online you can buy them in any truck stop they plug directly into your cig. lighter and work awsum. A great blog I found that may answer many of your questions is: I just found it the other day, the dude is a fantastic writer and wrote a small book addressing most issues you can think of regarding being homeless in a how to fashion.
Sleep is the ultimate key to a semi-permanent life on the road. Without the ability to consistently link several good nights’ of sleep, you will inevitably become a red-eyed, nerve shaken, road weary traveler who just can’t seem to down enough coffee. Invest in your sleep system knowing that satisfying this basic need is the first step in an epic road trip.
Sleeping will likely be a challenge at first because there is a good chance that your vehicle is not large enough for you to fully stretch out your body. Find a position where you can comfortably sleep with your legs bent or against your chest. Alternatively, you can try sitting up in the back seat and propping a pillow against the wall of the car.
Personal safety should always be your number-one priority. Keep your keys near (but not in) the ignition so you can drive off on a moment's notice. Knives used for food preparation and tire irons can be used as weapons. Pepper spray is another option. You may want to learn your state's gun laws and purchase a handgun or other firearm if you do not already own one. Criminals seek out people who appear vulnerable, or travel alone. Sometimes the sound of a cocked gun will be sufficient enough to deter a potential mugger. However, be aware that if police become aware that you have a gun, they may shoot you for possessing a weapon. Police generally do not regard homeless people well and there has been many unfortunate cases of shootings of homeless people (even unarmed ones) by police.[13]
Always have several types of can openers. Plastic spoons and forks are a good idea too. All can food can be eaten right out of the can. Maximize the space in your vehicle use soft duffel bags as these can be formed in to the small spaces in the vehicle. Use the area around the spare tire for extra storage. Use under the seats and the foot wells as well. keep the vehicle inside clean do not let trash and litter build up. and when you use the public rest room you can pick up some extra toilet paper. Just fold it up tightly and put in you pocket. You can refill the water bottles so you do not have to keep buying water. Look for a park with drinking fountains also around here a lot of the parks have grills that you can use. I just takes finding some wood that you can burn ( do not use painted or treated wood) dry sticks and branches work best. This way you can heat up some of your food. Dry instant oatmeal packs can be eaten as is as can ramen noddle’s save the flavor pack for a hot drink later.
I was a security officer for about 13 years, and I can truly tell you what cops and security look for: Things that are out of place…things that don’t seem like they belong there. For example, in an apartment complex, if you park with the other vehicles (blend in), and keep a low profile (no lights at night…cigarettes, lighters, reading lights, etc), then you probably won’t get noticed. However, if you park in a secluded spot, I can almost guarantee that you will get the attention that you don’t want. Cops and (professional, trained) security look at things in black and white: Normal, or NOT NORMAL. It’s the “NOT NORMAL” things that trigger a response. Keep that in mind and you’ll do fine. 🙂
I use Staples or Best Buy for Free Wifi. They block Myspace but I can still look things up. I own a little minivan and have been parking at Walmart in the same spot for a 2 months and have never gotten in trouble. There was even a finder bender right in front of my van once and a couple cops were walking around. I didn’t move, but I have sheets over my windows. Perhapes they just don’t care where I’m at or maybe they honestly didn’t notice me. Either way I’m getting pretty bold, I don’t even bother with my curtens some nights.
I bought a cheap gym membership close to the center of the city. I store a couple towels and my gym clothes in a locker and lock it so I dont have to store it in my car. The gym has signs saying you have to pay to rent a locker, if you want to keep your stuff there overnight, and all lockers not paid for can be cut and stuff removed by staff. I just change lockers every couple days or every day if I feel paranoid, Its a cheap gym how are they going to know.
Another great way to use electric heat pads in the cold weather is to put one on the car seat to get it warm before you get back to your vehicle. First attach it to a timer, so that the timer turns it on about 15 minutes before you plan to get back to your vehicle. The timer is plugged into the inverter, and you can use a small 70 watt plug in inverter for this – one that plugs into the cigarette lighter. They do 70 watts when the car is off and 140 watts when the car is running.

You need to keep your body and mind in good shape. Eat as good as you can and exercise regularly. You should already have a gym membership for the hot showers, take advantage of the gym since you are paying for it. Get at least 7 or 8 hours of sleep a night. You don’t need to have a huge social circle, but a few friends will help you from feeling lonely. If you can’t make friends, there are tons of people on line to talk with about whatever you want to(this conversation counts). Doing all of these things will keep the chemicals in your brain and body at healthy levels and keep you from such feelings as anxiety or depression. Also you should try to lift weights when you are at the gym. Heavy lifting increases your testosterone levels which will give you motivation.

I’ve been researching this for about six months since I knew my days were numbered. I’m considering around the San Diego area as my ideal destination. I know it’s a high cost of living there but I’ve found cheap motels and campsites nearby to stay as I look for a job. Plus I’m considering moving into Mexico as well. If you go right across the border rents are half as much. Lots of Americans live there and commute into San Diego to work. You only need a passport card which is much cheaper than a passport at $45. There is a “buffer zone” just south of the border where Mexico doesn’t enforce citizenship or VISAs. In fact if you go on San Diego craiglist right now there is a retired woman seeking a roommate in Mexico for $370 a month in a gated apartment complex close to the beach. You can even take your dog into Mexico if you have all the paperwork for shots. Do a search on Baja California and Playas De Rosarito and Playas De Tijuana. The weather is just like southern California so it’s beautiful year round. Which means very, very little spent heat/ac. And if you learned Spanish you could teach English in Mexico for extra income. Spanish is one of the easiest languages to learn. There’s a lot of Americans living there now so go read about them online. There’s tons of advice about it.
Car registration and insurance. You have to have these. Driving around in an unregistered car is just asking for trouble. Sooner or later you will get pulled over and it will cost you big money in fines. You can't afford to be throwing away money on fines, particularly as the cost of registration will be about the same as the fines. Also, if your car is unregistered then it is uninsured. The cost of an accident can be thousands at the low end, and millions at the high end. Apart from anything, if you are pulled over by police, you will be all legal, so they will be less likely to hassle you over other stuff.
To study the role of CAR in T2D, we crossed the CAR−/− allele into the ob/ob background to generate double mutant mice (ob/ob, CAR−/−). Loss of CAR function in the ob/ob background had no effect on a number of parameters, including body weight, food intake, fat-to-body weight ratio, and serum levels of triglycerides, cholesterol, and free fatty acids (Fig. S1 A–F). The lack of effect on serum triglycerides contrasts with a recent report using ob/ob, CAR−/− mice generated using a distinct CAR−/− allele (13). In that study, the effect on serum triglycerides was attributed to an activation of PPARα, which we did not observe in our ob/ob, CAR−/− mice (Fig. S1 G and H). We conclude that our ablation of CAR in the ob/ob background does not affect the obese phenotype.